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Valacyclovir has an average rating of 8. Unlike valacyclovir and acyclovir, which are usually prescribed for HSV-1 and HSV-2, famciclovir is typically used to treat shingles, or herpes zoster. 2 out of 10 from a total of 175 ratings on Drugs. It can also be used to treat chickenpox in children. Read on for a comparison of the two drugs.. 77% of reviewers reported a positive effect, while 10% reported a negative effect. Famciclovir was introduced in the 1990s by Novartis and is sold under as Famvir in the United States Famciclovir is another antiviral drug that’s used for certain herpes infections. Acyclovir is what is known as a nucleoside analog Dr. Acyclovir (Zovirax) is an antiviral medication used for the treatment of herpes, shingles, and chickenpox Zovirax (acyclovir) and Valtrex (valacyclovir) are antiviral medications. They are used against the following viruses: Herpes zoster, the virus that causes chickenpox and shingles. Valacyclovir has a higher oral bioavailability. Valacyclovir may be much more expensive than Acyclovir. Once it is converted into acyclovir the mechanism of action is similar to that of acyclovir Valacyclovir is superior to acyclovir in the treatment of herpes zoster. Valacyclovir undergoes liver metabolism as it goes through the liver, to enter the systemic circulation. Valtrex (valacyclovir) is an antiviral medication and is a first choice treatment for herpes virus infections including cold sores, genital herpes, and shingles. Famciclovir is another antiviral drug that’s used for certain herpes infections. After entering the body esterase enzymes convert it to acyclovir and Valine. Acyclovir has an average rating of 8. While both medications significantly shorten the periods of acute pain, time to complete zoster rash crusting and resolution, valaciclovir significantly accelerate the resolution of herpes zoster-associated pain compared with acyclovir5 Famciclovir. If you are paying out of pocket for these medications, you may discover that there is a steep pricing difference between the two. "Prepackaged" drug: Valacyclovir is exactly the same as acyclovir, except there is an additional chemical structure stuck to it, that allows the drug to be easily absorbed in the digestive system. 81% of reviewers reported a positive effect, while 12% reported a negative effect 7. Although both drugs target the same viruses, there are a few differences between them. This additional structures is then cleaved off in the liver to acyclovir It has a better bioavailability than acyclovir. Viruses attack by taking over a cell’s nucleus, where new DNA is made, forcing it to make viral DNA instead. 4 out of 10 from a total of 464 ratings on Drugs. For most pharmacies, you will find a much higher cost per tablet for Valacyclovir than for Acyclovir. Infectious Disease 19 years experience.